National Cancer Centre of Singapore Pte Ltd

Bioinformatics Specialist (Ref:DSSOPC)

Job Category:  Research
Posting Date:  08-Mar-2023

You will work as part of an established and nationally funded multi-disciplinary research group that focuses on hepatocellular carcinoma and other cancers. You will be involved in a large-scale international translational and clinical study on HCC, which utilizes various types of patient biosamples and employs multi-omics approaches including bulk tumor next-generation sequencing (NGS), cfDNA NGS, single cell RNAseq and proteomics, CyTOF, 3D spatial transcriptomics, and targeted/untargeted metabolomics in the context of a clinical cohort. 

Your responsibilities will include:
- Work within a sandbox environment using AWS.
- Assist the Principal Investigator in conceptualizing and conducting research projects. 
- Work collaboratively with scientific and clinical staff on data analysis and interpretation of in-house data by using various analytics tools and setting up analysis pipelines.
- Responsible for the coordination and management of the genomic projects of the multidisciplinary study.


- PhD degree in Computational Biology or a quantitative background (e.g. Statistics, Physics, Engineering), or Biomedical-related disciplines with a strong evidence of genomics computational experience.
- Candidates with MSc in Computational Biology or related discipline but with significant research experience may be considered.
- Experience with large-scale bioinformatics analysis (including, but not restricted to NGS, single cell sequencing, Chip-seq, cfDNA analysis, disease modelling, statistical and survival analysis).
- Experience in developing and implementing bioinformatics pipelines (such as GATK, bcbio, Nextflow, etc.) for analysing whole genome, whole exome and RNA sequencing data for variant calling, copy number and gene expression analysis.
- Proficient in using R packages (such as bioconductor, tidyverse, ggplot,etc.) or Python packages (such as pandas, NumPy, Scikit-learn, etc.) and good knowledge of Unix shell scripting.
- Knowledge wwith high performance computing (HPC) and cloud computing (AWS) will be an advantage. 
- Possess excellent analytical, technical and problem-solving skills.
- Well organized and detail oriented.
- Excellent written and verbal communication skills.
- Able to work with diverse groups of people.
- Good team worker and fast learner.