Research Officer (Ref:DMOAT)

We are seeking a highly motivated Research Officer to join the Division of Medical Oncology at National Cancer Centre Singapore. You will be part of a clinical and translational research team in Cancer Therapeutics Research Laboratory, working to translate genomics medicine into clinical practice. You will work closely with research fellows and clinicians to profile lung cancer across different malignancy stages and resistance track. You will be executing wet laboratory protocols including DNA extraction, bulk/single-cell RNA isolation, and lung organoid cultures. Experienced lab members will provide training and guidance.

Your responsibilities will include:
- Tissue logistics:
  - Tracking of biological samples received in the lab pertaining to the study.
  - Collection of patient samples (FFPE, Tissue, WBC, DNA or RNA) from Pathology.
  - DNA/RNA extraction from frozen tissue or FFPE.
  - Submission of DNA/RNA samples to external sequencing partner.
- Cell culture:
  - Generation of cell line and/or organoids, tissue explants from tissue collected from the study.
  - Maintenance of these cell lines and/or organoids in culture.
  - Upkeep records on preserved organoid bio-banked samples and assist with related efforts. 
  - Assist with molecular cloning efforts using cell line and organoid models.
- Perform tasks and support all aspects of the research project:
  - Perform literature reviews when required.
  - Plan and execute experiments for functional validation.
  - Conduct accurate monitoring, documenting and reporting of experimental result and research findings.
  - Evaluate and interpret collected data and prepare oral presentations/scientific manuscripts/ literature for publication.
  - Laboratory upkeep and maintenance.

Requirements:
- Bachelor/Master of Science degree in related technical discipline (biology, cell biology, biomedical science, biochemistry or molecular biology).
- Experience working in a clinical or academic environment.
- Strong technical/wet lab skills.
- Molecular cloning skills and prior experience with organoid and cell culturing are preferred.
- Team player with excellent communication skills and the ability to work independently.
- Independent worker, possess initiative to complete tasks and projects assigned.
- Highly motivated to learn new techniques and not afraid to ask if unsure.
- Able to undertake independent research progressively.