Senior Research Officer, SingHealth Translational Immunology and Inflammation Centre (Contract)

Join the SingHealth Translational Immunology and Inflammation Centre (STIIC), where cutting-edge immunotherapy research meets clinical application. You will be part of a multidisciplinary team working on regulatory T cell-based therapies for autoimmune and inflammatory diseases, contributing directly to research that has the potential to transform patient care.

We are seeking a Senior Research Officer to support our preclinical research programme focused on CAR-Treg immunotherapies, whilst maintaining the high standards of documentation and rigor required for translational research that may advance to clinical trials.

What You Will Do:

You will execute experiments related to CAR-Treg functional validation both in vitro and in vivo, including the isolation, activation, expansion, and characterisation of human and mouse regulatory T cells. Your work will involve conducting lentiviral transduction with GMP-grade vectors followed by comprehensive functional validation and executing preclinical autoimmune disease models including humanised graft-versus-host disease, collagen-induced arthritis, and inflammatory bowel disease models. You will process tissue samples for various analytical platforms including flow cytometry, CyTOF, spatial analysis, and single cell RNA technologies. Additionally, you will support administrative aspects of the Innovation and Acceleration Fund Principal Pilot project through project reporting, data summaries, and documentation relevant to translational studies. You will coordinate optimisation of laboratory workflows in close collaboration with external stakeholders such as clinical research institutes and lentiviral production companies to ensure alignment with clinical translation requirements.

Job Requirements:

• Bachelor's degree in Life Science, Biology, Molecular Biology, Immunology or related fields

• Three to five years of research experience in laboratory, industry, or start-up environments
• Preferably with experience in immunology-focused laboratories with knowledge of flow cytometry, immunotherapy, and mouse models
• Adaptable and positive individual with ability to multitask laboratory and administrative work
• Strong team collaboration skills with ability to deliver against tight timelines
• Experience with experimental troubleshooting and protocol optimisation
• Ability to work independently and as part of a multidisciplinary team